ESPE Research Unit

The ESPE Research Unit is a collaborative research grant coordinating high quality research in paediatric endocrinology for both physicians and scientists.

One large grant and one small grant are funded annually. The larger grant of €130,000 is for a period of two years (up to €65,000 per year) and the smaller grant of €15,000 is awarded for a period of one year.

Preliminary applications for the large grant have now been reviewed and final applications have been requested.

We are opening a new call for small grant applications. If you would like to apply, please complete the final application form by 30 April.

Supported by an unrestricted grant from Sandoz.

30 Apr
Application Deadlines


Specific Requirements
  • ESPE Research Unit awards can only be submitted by ESPE members who intend to support collaborative research among members.
  • Non–ESPE members may participate as co–investigators.
  • We consider that the bulk of the research should be performed at the investigators laboratory / hospital sites.
  • Current members of the Science Committee and ESPE Council are not eligible to apply for this grant 
  • A grant must be activated within 6 months of receipt

Selection Criteria

The applications will be scored based on the following criteria:
  • Presence of hypothesis (clear aims)
  • Originality
  • Scientific importance
  • Experimental design
  • Principle investigator qualifications
  • Co-investigator qualification
  • Budget
  • Mode of Collaboration


Evaluation Procedure

  • All preliminary applications will be assessed for eligibility by the ESPE Research Unit Convenor and Science Committee.
  • All applications that fulfil the initiative of the grant will be invited to submit a final application for the collaborative research grant.
  • All final applications will be subjected to an external peer review by at least three experts in the field on the Science Committee Expert Panel.
  • Ranking is made by each reviewer independently based on the named selection criteria, the highest ranked projects are granted.
  • The ESPE Science Committee can decide to allocate only one grant in case of insufficient quality.

Further Information

How to Apply

Please read the Application Guide before completing the preliminary application form.

If your preliminary application is successful, you will be invited to submit a final application, which should consist of the following:

  • Final Application Form
  • Research programme
  • CV of all investigators
  • Additional supporting documents if required

It is essential that application forms are fully completed, including the necessary signatures.


  • Preliminary Application – 26 February 2018
  • Final Application – 30 April 2018

2017-2019 ESPE Research Unit Grant

"Personalized approach to non-syndromic childhood obesity using multi-omics disease signature"

Investigators: Aneta Gawlik (Poland), Ze’ev Hochberg (Israel), Stefan A. Wudy (Germany), Michael Shmoish (Israel), Malgorzata Wasniewska (Italy), Abdullah Bereket (Turkey) 


"Comparison of the short and medium term side effects of first bisphosphonate infusion between children with different underlying bone pathologies."

Investigators: Moira Cheung (UK), Wolfgang Högler (UK), Oliver Semler (Germany), Adalbert Raimann (Austria) 


2016–2018 ESPE Research Unit Grant

"Improvement of Diagnostic workup for congenital hypothyroidism by a multigene NGS panel: A multicenter study to compare diagnostic accuracy and cost effectiveness"

Investigators: Gabor Szinnai , Johnny Deladoëy , Michel Polak, Heiko Krude, Paul van Trotsenburg, Switzerland, Canada, France, Germany, Netherland


"Identification of novel genetic causes of familial central precocious puberty"

Investigators: Magdalena Stefanija Avbel, Liat de Vries,Taneli Raivio, Slovenia, Israel, Finland


"YESS! Introduction of the Young Endocrine Support System in the transition from paediatric to adult endocrine care"

Investigators: Laura de Graaff, Sabine Elisabeth Hannema, Martine Cools, Gary Butler, Jesus Argente, Netherland, Belgium, UK, Spain


2015–2016 ESPE Research Unit Grant

"In search for novel monitoring tools to detect chronic over- or under-treatment in children with CAH"

Investigators: E van den Akker, E. Charmandari, C. Flueck. Netherland, Greece, Switzerland


2014–2016 ESPE Research Unit Grant

"Cellular Modelling of Human Gonad Sex-Determination"

Investigators: Anu Bashamboo, Ken McElreavey, Raja Brauner. Andy Greenfield, Radha Saraswathy, Faisal Ahmed. France, UK, India


"Managing clitoromegaly in childhood in girls with CAH: an investigation of the psychological impact of current treatment strategies"

Investigators: Elisabeth Crowne, Julie Alderson, Naomi Crouch, Faisal Ahmed, Bristol, Glasgow, UK


2014–2015 ESPE Research Unit Small Grant

"Overnight Glucose Control with MD-Logic Artificial Pancreas System in Young Children with Type 1 Diabetes"

Investigators: Susan M O'Connell, Amir Shafat, Bruce King, Ireland, Australia


2012–2014 ESPE Research Unit Grant

"Understanding the molecular basis of diabetes mellitus associated with novel syndromes."

Investigators: K Hussain, K Raile, F Darendeliler. United Kingdom, Germany, Turkey


"The impact of obesity on the molecular mechanisms involved in the development of metabolic abnormalities in children and adolescents."

Investigators: B Spiliotis, W Kiess, J Argente. Greece, Germany, Spain


2011–2012 ESPE Research Unit Grant

"New Genes for Neonatal Diabetes (ND) and Hyperinsulinemic Hypoglycemia (HH)."

Investigators: F Barbetti, RW Holl, CG Nichols. Italy, Germany, USA


"Study of early endocrine profile in infants with Prader-Willi syndrome (PWS) in order to unravel the switch from early feeding difficulties to obesity and hyperphagia."

Investigators: M Tauber, A Hokken–Koelaga, B Hauffa, A Goldstone V Beauloye, R Nergardh. France, Netherland, Germany, United Kingdom, Belgium, Sweden


"Abnormal Thyroid Development: a Model Disorder for Congenital Malformations and Neurocognitive Development."

Investigators: J Deladoey, M Polak, S Costagliola, G Van Vliet. Canada, France, Belgium


"EuroPHPnet, a unique tool to decipher the Gsa dependent signalling pathways."

Investigators: A Linglart, C Silve, O Hiort, S Thiele, S Fischer, L De Sanctis, A Spada, G Perez De Nanclares, K Freson. France, Germany, Italy, Spain, Belgium


2010–2011 ESPE Research Unit Small Grant

No grant was given


2010–2012 ESPE Research Unit Grant

"Infant manifestations of adult obesity susceptibility genotypes"

Investigators: K. Ong, B. Heude, L. Ibáñez, D. Dunger, MA Charles, F. de Zegher; from UK, France, Spain, Belgium


2009–2011 ESPE Research Unit Grant

"Effects of endocrine disrupting chemicals (EDC) on GnRH neuronal function."

Investigators: S Heger, A–S Parent, V Prevot; from Germany, Belgium, France


"Congenital Hyperinsulinism: Genes, phenotype and treatment."

Investigators: HB Christesen, V Peterkova, AN AlMutair, K Brusgaard; from Denmark, Russia, Saudi Arabia


2008–2010 ESPE Research Unit Grant

"Anti–Müllerian hormone levels in girls with Turner's syndrome: A possible predictor of ovarian function."

Investigators: CE Flück, JA Visser, MB Ranke, A Hokken-Koelege; from Switzerland, The Netherlands, Germany


2008–2009 ESPE Research Unit Small Grant

"Safety and Appropriateness of Growth Hormone treatments in Europe (SAGHE)"

Investigators: JC Carel; S Cianfarani, G Butler, L Savendahl; from France, Italy, UK, Sweden


"Endocrine and Genetic Characteristics of the Pygmy Population in South Western Uganda"

Investigators: Z Hochberg, E Mworozi, C Camacho-Hübner, M. Dattani; from Israel, Uganda, Sweden, UK


2007–2009 ESPE Research Unit Grant

"Molecular regulation of normal thyroid development and function and their diseases"

Investigators: M Polak, G. Szinnai, J. Moreno; from France, Switzerland, Netherlands


"Investigation of mitochondrial function and alterations in the mitochondrial proteome during development of obesity"

Investigators: AN Eberle, P Liniger, IM Fearnley, JE Walker, R Peterli, T Peters, U Zumsteg, J Mayr; from Switzerland, England


2007–2008 ESPE Research Unit Small Grant

"Identification of ABCC8 mutations in atypical type 1 diabetes patients and possible treatment consequences"

Investigators: PR Njølstad, A Molven, HB Mortensen, L Castaño; from Norway, Denmark, Spain


2006–2008 ESPE Research Unit Grant

"Exploring the utility of a European register of disorders of sex development / DSD"

Investigators: SF Ahmed, O Hiort, S Bertelloni, IA Hughes, SLS Drop, K Robertson, from Scotland, England, Germany, Italy, Netherlands


2006–2007 ESPE Research Unit Small Grant

No grant was given


2005–2007 ESPE Research Unit Grant

"Molecular regulation of the growth plate"

Investigators: J M Wit, L Sävendahl and G Rappold from The Netherlands, Sweden and Germany


2005–2006 ESPE Research Unit Small Grant

"Networking in Paediatric Endocrine Disruptors"

Investigators: J Toppari, J Anders, O Söder, JP Bourguignon, I Hughes, C Acerini, C Sultan from Finland, Denmark, Sweden, Belgium, United Kingdom, France


2004–2006 ESPE Research Unit Grant

"Screening and characterisation of DAX1–Interacting Proteins"

Investigators: A Tiulpakov, P Rubtson, W Sippell, N Krone and J Achermann from Russian Federation, Germany and United Kingdom.


2004–2005 ESPE Research Unit Small Grant

"Effects ACE-inhibitors on endothelial dysfunction and markers of angiopathy and oxidative stress in adolescent and young adults with type 1 diabetes"

Investigators: Angelika Mohn, M Vanelli, T Danne and H. Mortensen from Italy, Germany and Denmark


2003–2005 ESPE Research Unit Grant

"Rickets in Children of Middle Eastern Origin"

Investigators: G Saggesse, G Baroncelli, L Audi, A Bereket, H Delemarre–van de Waal, M El Kholy, Z Hochberg, E Schonau, N Shaw from Italy, Spain, Turkey, The Netherlands, Egypt, Israel, Germany and United Kingdom.


2002 ESPE Research Unit Small Grant

"The role of the Ihh/PTHrP feedback loop in the human growth plate: A concerted European action"

Investigators: L Sävendahl. JM Wit, H Robson, GR Williams, P Moshe, I Hughes, T Siebler, M Corvol, S van Buul-Offers from Sweden, The Netherlands, United Kingdom, Israel, and Germany.


2001–2003 ESPE Research Unit Grant

"Collaborative international studies on the long term effects of Prenatal Treatment of Congenital Adrenal Hyperplasia (PREDEX)"

Investigators: M Ritzén, A Wedell, S Lajic, R Voutilainen, K Main, M Ginalska–Malinowska, C Brain, P Hindmarsh, L Ibañez, M Forest from Sweden, Finland, Poland, Denmark, United Kingdom, Spain and France.